Escalation of drug resistant microbes (bacteria) had forced researchers to search new and im-proved therapeutic compounds from different possible sources, including metabolites secreted by the actinomycetes. The aim of this study was to evaluate the pattern of antimicrobial actinomy-cetes from physiologically distinct soil of different geographical locations. Forty five soil samples were collected from 5 districts of Gujarat including two sanctuaries as source of survey for bioac-tive actinomycetes. Crowded plate technique was used for isolation and Agar cylinder method was employed for the antimicrobial screening. A total of 171 actinomycetes were isolated and screen-ed against eighteen pathogens responsible for causing diseases in plants and humans. Results in-dicate that 79% of the isolates were active against at least one of the eighteen tested pathogens. Some of the actinomycetes strain had shown strong antibacterial and antifungal activity which may be a good source of obtaining novel antimicrobials.
Patel, J. D., Parmar, M., Patel, P., Rohit, P., Taviyad, R., Ansari, P., … Singh, P. K. (2014). Dynamism of Antimicrobial Activity of Actinomycetes—A Case Study from Undisturbed Microbial Niche. Advances in Microbiology, 04(06), 324–334. https://doi.org/10.4236/aim.2014.46039