Antagonistic and cyto-toxicity activity of mollusc methanol extracts

Abstract

Marine mollusc paved a way for the isolation of bioactive compounds. Therefore, the present study was to investigate the Antimicrobial and cytotoxicity activities on 25 mollusc samples. The antibacterial activity was conducted against six human pathogens and anti fungal activity was tested against two fungal strains by the disc diffusion method. Further, in vitro toxicity assays such as hemolytic activity was done in microtiter plates method and Brine shrimp toxicity assay were tested against Artemia μg. The potent antibacterial activities were found against Staphylococcus aureus, Vibrio cholera and Salmonella paratyphi and the high degree of anti fugal activity in Aspergillus fumigatus than Fusarium sp. The hemolytic activity was detected in Meretrix casta, Sepia officinalis, Lophiotoma indica, Octopus vulgaris, Sepia officinalis ink, Ficus ficus, Xancus pyrum, Natica picta, Turrittella attenuata, Architectonica sp. The Brine Shrimp toxicity (LC50) was also found in Conus betilinus, Hemifusus pugilinus, Burselltalla leachi, Lambis lambis, Ficus ficus, Conus adustus. The results revealed that mollusc samples are a promising source for identifying novel drug lead compounds. © Asian Network for Scientific Information.