We herein report a 15-year-old girl who developed rapid progressive muscle weakness soon after the third injection of a bivalent human papilloma virus (HPV) vaccine. Although immunotherapies were performed for possible vaccine-related disorders, she died of respiratory failure 14 months after the onset of the disease. A genetic analysis identified a heterozygous p.P525L mutation of the fused in sarcoma (FUS) gene, and a histopathological analysis was also consistent with FUS-associated amyotrophic lateral sclerosis (ALS) without any evidence of neuroinflammation. We concluded the diagnosis to be FUS-ALS, although we cannot completely rule out the possibility that the vaccination worked as a trigger.
CITATION STYLE
Hikiami, R., Yamakado, H., Tatsumi, S., Ayaki, T., Hashi, Y., Yamashita, H., … Takahashi, R. (2018). Amyotrophic lateral sclerosis after receiving the human papilloma virus vaccine: A case report of a 15-year-old girl. Internal Medicine, 57(13), 1917–1919. https://doi.org/10.2169/internalmedicine.0285-17
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