Erratum: Challenges associated with homologous directed repair using CRISPRCas9 and TALEN to edit the DMD genetic mutation in canine Duchenne muscular dystrophy (PLoS ONE (2020) 15:1 (e0228072) DOI: 10.1371/journal.pone.0228072)

Abstract

In the Abstract, there is an error in the seventh sentence. The terms sgRNA A and sgRNA B should be swapped. The correct sentence is: On western blot analysis, protein expression of up to 6% of normal levels was seen in two dogs injected with sgRNA A and up to 16% of normal in one dog treated with sgRNA B. There is an error in the caption for Fig 6, "Dystrophin expression was minimally restored in HDR-CRISPR-Tx muscle from sgRNA A,"while referring to Miercoles and "Clove."The correct caption should say Miercoles and "Friendly,"as per Table 1. Please see the complete, correct Fig 6 caption here. There is a similar error in the caption for S8 Fig, "Dystrophin expression was minimally restored in HDR-CRISPR-Tx muscle from sgRNA B,"while referring to Bubbles and "Friendly."The correct caption should say Bubbles and "Clove,"as per Table 1. Please see the complete, correct S8 Fig here. There is an error in the caption for S12 Fig, "Force normalized for body weight (N/kg) values from GRMD dogs before and after HDR treatment and eccentric contraction decrements (ECD)."The panel "Flexion tetanic values"should be cited before the panel "extension tetanic values."Please see the complete, correct S12 Fig here. In the Discussion, there is an error in the second sentence of the fifth paragraph. The correct sentence is: Miercoles was the only dog in which the mRNA and protein values tended to track together. The images for S4 Fig and S5 Fig are incorrectly switched. The image that appears as S4 Fig should be S5 Fig, and the image that appears as S5 Fig should be S4 Fig. The figure captions appear in the correct order. (Figure Presented).