Drug-induced hepatic injury

Abstract

Objective: To reveal the new recognition of drug-induced hepatotoxicity. Methods: The literature in the recent years are reviewed. Results: The liver is the important organ for the drug metabolism. Drug-induced hepatic injury accounts for more than 50% of the cases of acute liver failure in the USA in recent years and is the most frequent reason for an approved drug withdrawal from the market. In order to improve this condition it is necessary to carry out a comprehensive investigation of drug hepatotoxicity. Conclusion: The pathogenesis of drug-induced hepatotoxicity, adverse drug reactions that involve the liver, and the process of drug approval should be understood.