Spectomycins, new antibacterial compounds produced by streptomyces spectabilis: Isolation, structures, and biosynthesis

Abstract

Three new tetrahydroanthracene antibiotics have been isolated from modified culture broths of Streptomyces spectabilis. The new compounds, spectomycins A1, A2 and B1, exist as monomeric (C20H20O7, Al; C19H18O7, A2) and as symmetrical dimeric (C38H34O14; B1) forms. Only spectomycin Bl has moderate activity against Gram-positive microorganisms. We report here the structure elucidation and biosynthetic origin of these compounds. © 1994, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.