Severe acute pancreatitis with blood infection by Candida glabrata complicated severe agranulocytosis: A case report

Abstract

Background: Blood infection with Candida glabrata often occurs in during severe acute pancreatitis (SAP). It complicate severe agranulocytosis has not been reported. Case presentation: We present a case where a SAP patient presenting with a sudden hyperpyrexia was treated for 19 days. We monitored her routine blood panel and CRP levels once or twice daily. The results showed that WBC count decreased gradually. And the lowest level of WBC was appeared at the 21st day of treatment. WBC 0.58 × 10 9 /L(4.0-10.0 × 10 9 /L), neutrophils 0.1 × 10 9 /L [2.20%] (2.5-7.5 × 10 9 /L). During treatment, Candida glabrata was identified as the infecting agent through blood culture, drainage tubes culture and gene detection. During anti-infection therapy, the patient had severe agranulocytosis. With control of the infection, her WBC and granulocyte counts gradually returned to the normal range. Conclusions: Blood infection with Candida glabrata can complicate severe agranulocytosis.