High coagulant factors & venous thrombosis

Abstract

In this issue of Blood, results from the Longitudinal Investigation of Thromboembolism (LITE)1 show that, of the coagulant factors IX through XIII, only elevated levels of procoagulant factor XI were associated with a first venous thrombosis. LITE is the first prospective cohort study reporting on all these factors. Factor IX initially appeared to be associated with thrombosis but, after adjustment for primarily body mass index, the association disappeared.