Preparation of Pickering Emulsion for Antibacterial, Anti-Inflammatory and Wound Healing

Abstract

In recent years, natural biodegradable nanoparticles as stabilizers of Pickering emulsions have attracted extensive attention. In this work, a Pickering emulsion composed of chitosan/Arabic gum nanoparticles (CS/GA NPs), tea tree oil and vitamin E was formulated. Then the antibacterial, anti-inflammatory and wound healing abilities of the emulsion were evaluated. Pickering emulsion encapsulated the tea tree oil strengthened antibacterial activity towards Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans. Besides, this multi-phase system offered a platform to load with vitamin E, which provides anti-inflammatory effects while antibacterial. Meanwhile, Pickering emulsion avoided contact between bacteria and skin when used in wound treatment.