Annulations involving 1-indanones to access fused- and spiro frameworks

Abstract

Indanones are prominent motifs found in number of natural products and pharmaceuticals. Particularly, 1-indanones occupy important niche in chemical landscape due to their easy accessibility and versatile reactivity. In the past few years, significant advancement has been achieved regarding cyclization of 1-indanone core. The present review focuses on recent (2016-2022) annulations involving 1-indanones for the construction of fused- and spirocyclic frameworks. In this context, new strategies for synthesis of various carbocyclic as well as heterocyclic skeletons are demonstrated. Mechanistic aspects of representative reactions are illustrated for better understanding of reaction pathways. A large number of transformations described in this review offer stereoselective formation of desired polycyclic compounds. Importantly, several reactions provide biologically relevant compounds and natural products, such as, plecarpenene/plecarpenone, swinhoeisterol A, cephanolides A-D, diptoindonesin G and atlanticone C.