Polyhydroxylated steroids and other constituents of the soft coral Nephthea chabroli

Abstract

Polyhydroxylated steroids and other metabolites were isolated from the soft coral Nephthea chabroli collected in South China Sea. The structures of two new compounds were determined to be 24-methylcholesta-9(11), 24(28)-diene-3β, 12α,19-triol and 4α-methyl-3β,14β-dihydroxy-5α- ergost-24(28)-en-23-one on the basis of spectroscopic analysis. Cytotoxic activities of the polyhydroxylated sterols were evaluated on prostate carcinoma LNCaP cell line. © 2003 Pharmaceutical Society of Japan.