Src-dependent tyrosine phosphorylation of non-muscle myosin heavy chain-IIA restricts Listeria monocytogenes cellular infection

Abstract

Background: Non-muscle myosin IIA is involved in force generation, movement, and membrane reshaping. Its activity is regulated by phosphorylation of the light chain. Results: NMHC-IIA head domain is tyrosine-phosphorylated by Src and modulates Listeria intracellular levels. Conclusion: Tyrosine phosphorylation of NMHC-IIA affects the outcome of infection. Significance: This novel post-translational modification of NMHC-IIA possibly affects its functions.