Experimental design for vector output systems

Abstract

We formulate an optimal design problem for the selection of best states to observe and optimal sampling times for parameter estimation or inverse problems involving complex non-linear dynamical systems. An iterative algorithm for implementation of the resulting methodology is proposed. Its use and efficacy are illustrated on two applied problems of practical interest: (i) dynamic models of HIV progression and (ii) modelling of the Calvin cycle in plant metabolism and growth. © 2013 © 2013 Taylor & Francis.