Organic dust to×icity (pulmonary mycoto×icosis) associated with silo unloading

Abstract

An acute febrile illness associated with unloading silos occurs more frequently than any other farm associated respiratory illness in mid state New York. This report describes 29 cases of organic dust to×ic syndrome (also known as pulmonary mycoto×icosis) occurring in 24 men and one woman with a mean age of 29 years. In 16 instances more than one worker was e×posed to the dust, and in 12 of these shared e×posures more than one worker became ill. Patients presented 5-3 (SD 3 3) hours after inhalation of organic dust and mould with fever (79%), myalgia (76%), chest tightness (72%), cough (66%), and headache (59%). The mean temperature was 38 7°C and the mean white blood cell count 13-2 × 109/1. In contrast to patients with allergic alveolitis, nearly all these patients had normal breath sounds, chest radiographs, and arterial o×ygen saturation. Tests for precipitating antibodies to farmer's lung disease antigens gave negative results in all 26 episodes in which they were done; of these, 10 had no evidence of precipitating antibodies to an aqueous e×tract of the silage associated with their own illness. Organic dust to×ic syndrome appears to be a common and substantial respiratory hazard to young farm workers. Despite being frequently misdiagnosed as farmer's lung, organic dust to×ic syndrome is clearly a distinctly different disease process.