METOPROLOL—CONTROLLED RELEASE, ZERO ORDER KINETICS

Abstract

Metoprolol CR/ZOK (controlled release, zero order kinetics) is a new formulation of an extensively used β1‐selective, β‐adrenoceptor blocking drug, (β1,‐blocker), designed to provide continuous, even, plasma concentrations in the therapeutic range. It should, therefore, provide an effective well‐tolerated treatment for hypertension and angina pectoris and for use in secondary prevention following a myocardial infarct. The purpose of this review is to consider the need for such a formulation, to describe its pharmaceutical development, review its pharmacology and assess its efficacy and tolerability compared with other available agents. Copyright © 1989, Wiley Blackwell. All rights reserved