A system review and meta-analysis of the treatment of acute angle-closure glaucoma under optical coherence tomography

Abstract

Background: A meta-analysis was conducted to investigate the value of treatment-related indicators of acute angle-closure glaucoma (AACG) based on optical coherence tomography (OCT) to evaluate the curative effect. Methods: Articles on the treatment of AACG in clinical research of OCT published from January 2010 to June 2020 were retrieved from the PubMed, Web of Science, and Spring databases. RevMan 5.3 software was used for the meta-analysis of the relevant data. The angle opening distance (AOD), trabecular-iris space area (TISA), angle recess area (ARA), anterior chamber depth (ACD), anterior chamber width (ACW), anterior chamber area (ACA), anterior chamber volume (ACV), lens vault (LV), iris thickness 750 (IT750), intraocular pressure (IOP), and pupil diameter (PD) values were observed and compared before and after the treatment. Results: A total of 12 articles were included in the meta-analysis. The results indicated that patients’ ACD, I-Area, IOP, and PD values were lower after treatment than before treatment [mean deviation (MD): –0.32, 0.12, –0.04, 13.55, 0.30; 95% confidential interval (CI): –0.55 to –0.08, 0.04 to 0.1, –0.09 to 0.01, 4.71 to 22.39, 0.09 to 0.529; Z=2.66, 3.06, 1.39, 3, 2.75, and P=0.008, 0.002, 0.16, 0.003, 0.006, respectively]. The ACA, ACV, ARA, AOD750, and TISA500 values were higher after treatment than before treatment (MD: –3.22, –2.90, –0.03, –0.05, –0.01; 95% CI: –5.07 to –1.38, –5.44 to –0.36, –0.05 to –0.02, –0.08 to –0.03, –0.02 to –0.01; Z=3.42, 2.24, 4.10, 4.41, 7.77, and P=0.0006, 0.03, <0.0001, <0.0001, and <0.0001, respectively). The ACW, LV, I-Curve, IT750, AOD500, and TISA750 values showed little change (MD: 0.01, 0.05, 0.075, 0.05, –0.07, 0.02; 95% CI: –0.04 to 0.05, –0.01 to 0.11, 0 to 0.15, –0.08 to 0.17, –0.16 to 0.02, –0.03 to 0.07; Z=0.29, 1.65, 1.85, 0.72, 1.49, 0.79, and P=0.77, 0.10, 0.06, 0.47, 0.14, 0.43, respectively). Discussion: The different indicators were not compared with the control group in this study, but it still could provide a reference for the selection of OCT diagnostic parameters before and after the treatment of AACG in the future.