SOCS3 Deletion in B Cells Alters Cytokine Responses and Germinal Center Output

  • Jones S
  • White C
  • Robb L
  • et al.
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Abstract

B cell behavior is fine-tuned by internal regulatory mechanisms and external cues such as cytokines and chemokines. Suppressor of cytokine signaling 3 (SOCS3) is a key regulator of STAT3-dependent cytokine responses in many cell types and has been reported to inhibit CXCL12-induced retention of immature B cells in the bone marrow. Using mice with SOCS3 exclusively deleted in the B cell lineage (Socs3Δ/Δmb1cre+), we analyzed the role of SOCS3 in the response of these cells to CXCL12 and the STAT3-inducing cytokines IL-6 and IL-21. Our findings refute a B cell-intrinsic role for SOCS3 in B cell development, because SOCS3 deletion in the B lineage did not affect B cell populations in naive mice. SOCS3 was strongly induced in B cells stimulated with IL-21 and in plasma cells exposed to IL-6. Its deletion permitted excessive and prolonged STAT3 signaling following IL-6 stimulation of plasma cells and, in a T cell-dependent immunization model, reduced the number of germinal center B cells formed and altered the production of Ag-specific IgM and IgE. These data demonstrate a novel regulatory signal transduction circuit in plasma cells, providing, to our knowledge, the first evidence of how these long-lived, sessile cells respond to the external signals that mediate their longevity.

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Jones, S. A., White, C. A., Robb, L., Alexander, W. S., & Tarlinton, D. M. (2011). SOCS3 Deletion in B Cells Alters Cytokine Responses and Germinal Center Output. The Journal of Immunology, 187(12), 6318–6326. https://doi.org/10.4049/jimmunol.1102057

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