Synthesis of O2'-methyluridine, O2'-methylcytidine, N4,O2'-dimethylcytidine and N4,N4,O2'-trimethylcytidine from a common intermediate.

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Abstract

A facile synthesis of the title compounds from a readily accessible precursor, 3',5'-O-bis-protected O4-(2-nitrophenyl)uridine, is described.

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Nyilas, A., & Chattopadhyaya, J. (1986). Synthesis of O2’-methyluridine, O2’-methylcytidine, N4,O2’-dimethylcytidine and N4,N4,O2’-trimethylcytidine from a common intermediate. Acta Chemica Scandinavica. Series B: Organic Chemistry and Biochemistry, 40(10), 826–830. https://doi.org/10.3891/acta.chem.scand.40b-0826

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