Millifolides a-c. new 1,10-seco-guaianolides from the flowers of Achillea millefolium

Abstract

Ten 1,10-secoguaianolides were isolated from the flowers of Achillea millefolium. Their structures were determined on the basis of spectroscopic methods. Three of them (millifolides A-C) including two dimeric sesquiterpenoids exhibit new skeletons. Seco-tanapartholide A exhibited moderate cell growth inhibitory activity against the human cancer cell line MCF7WT (IC50 = 5:51μm) in vitro. © 2012 Verlag der Zeitschrift für Naturforschung.