Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum

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Abstract

The antineoplastic constituents of the marine ascidian Aplidium californicum were found to be bryostatins 4 and 5. Bioassay-directed isolation procedures using the National Cancer Institute's P-388 lymphocytic leukemia system led to the bryostatins. The probable symbiotic relationship between A. californicum and the bryozoan Bugula neritina was discussed. © 1986, American Chemical Society. All rights reserved.

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Pettit, G. R., Leet, J. E., Herald, C. L., Kamano, Y., & Doubek, D. L. (1986). Antineoplastic Agents, 116. An Evaluation of the Marine Ascidian Aplidium Californicum. Journal of Natural Products, 49(2), 231–235. https://doi.org/10.1021/np50044a006

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