Lithium tri-sec-butylborodeuteride: A new reagent for the stereoselective deuterium addition to cyclohexanones with single chair conformations

Abstract

The preparation and application of a new reagent for stereoselective deuterium addition to substituted cyclohexanones is described affording cyclohexanols with axial hydroxy group with high stereoselectivity. The results are compared with other established reduction methods.