Nitrene-Mediated C−H Oxygenation: Catalytic Enantioselective Formation of Five-Membered Cyclic Organic Carbonates

Abstract

The synthesis of non-racemic 5-membered cyclic carbonates from abundant alcohols is reported. Conversion of the alcohol into an azanyl carbonate is followed by a chiral-at-ruthenium catalyzed cyclization to provide chiral cyclic carbonates in yields of up to 95 % and with up to 99 % ee. This new synthetic method is proposed to proceed through a nitrene-mediated intramolecular C(sp3)−H oxygenation which includes an unusual 1,7-hydrogen atom transfer within a ruthenium nitrene intermediate. The method is applicable to the synthesis of non-racemic chiral mono-, di- and trisubstituted cyclic alkylene carbonates.