Three-Dimensional Phase-Sensitive Inversion-Recovery Turbo FLASH Sequence for the Assessment of Left Ventricular Myocardial Scar in Swine

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Abstract

Objectives: We sought to evaluate the feasibility and accuracy of free-breathing three-dimensional (3D) phase-sensitive inversion-recovery (PSIR) Turbo FLASH sequence for noninvasive assessment of left ventricular myocardial scar in swine models.Materials and Methods:Nine Chinese minipigs with experimentally induced acute myocardial infarction were studied. At 1 week and the study endpoint 4 weeks after myocardial infarction surgery, the 3D and 2D contrasted cardiac magnetic resonance (CMR) imaging were performed randomly by using a 1.5T clinical MR imaging system. Comparisons of myocardial scar volume (in cubic centimeters), scar transmurality (on a 5 points scale) and image quality (on a 4 points Likert scale) were performed by using the Pearson correlation and Bland-Altman analysis (for myocardial scar volume) or κ statistics (for transmurality) or Wilcoxon signed rank test (for image quality).Results:In 6 of the 9 pigs, all procedures were successfully completed. In these pigs, a total of 48 segments with myocardial scars were detected by both 3D and 2D sequences, and there was good agreement for classification of scar transmurality (κ=0.930). The scar volume determined by triphenyltetrazolium chloride (TTC) staining (3.52±1.40cm3) showed a good correlation with both 3D (3.54±1.36cm3, r=0.957, P=0.003) and 2D sequence (3.53±1.26cm3, r=0.942, P=0.005) at 4 weeks. And there were good correlation between scar volumes obtained from 3D and 2D techniques (r=0.859, P<0.001) at both time points. Both 3D and 2D images detected a small reduction of scar volume from week 1 to week 4 by a factor of 1.179 and 1.176, respectively. Although slightly more artifacts were observed on 2D PSIR images, the overall image quality was not significantly different between the two sequences (3.17±0.83 for 2D vs. 3.25±0.75 for 3D, P =0.655).Conclusions:The free-breathing 3D PSIR Turbo FLASH sequence enables accurate assessment of left ventricular myocardial scar. © 2013 Chen et al.

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Chen, X., Lu, M., Yin, G., Zhao, T., Shao, X., Zhao, R., … Zhao, S. (2013). Three-Dimensional Phase-Sensitive Inversion-Recovery Turbo FLASH Sequence for the Assessment of Left Ventricular Myocardial Scar in Swine. PLoS ONE, 8(10). https://doi.org/10.1371/journal.pone.0078305

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