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Hardy-Weinberg testing of a single homozygous genotype

Genetics (2005) 170(3) 1439-1442
DOI: 10.1534/genetics.105.043190
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Abstract

No proper statistical test is available for the evaluation of deviation of a single homozygous genotype from Hardy-Weinberg equilibrium (HWE) proportion. We propose a 1-d.f. χ2-test. The power of the proposed test is favorable compared to existing HWE testing procedures. The applications of this test are discussed. Copyright © 2005 by the Genetics Society of America.

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Chen, J. J., Duan, T., Single, R., Mather, K., & Thomson, G. (2005). Hardy-Weinberg testing of a single homozygous genotype. Genetics, 170(3), 1439–1442. https://doi.org/10.1534/genetics.105.043190

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