Protection against foot-and-mouth disease virus in Guinea pigs via oral administration of recombinant Lactobacillus plantarum expressing VP1

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Abstract

Mucosal vaccination is an effective strategy for generating antigen-specific immune responses against mucosal infections of foot-and-mouth disease virus (FMDV). In this study, Lactobacillus plantarum strains NC8 and WCFS1 were used as oral delivery vehicles containing a pSIP411-VP1 recombinant plasmid to initiate mucosal and systemic immune responses in guinea pigs. Guinea pigs were orally vaccinated (three doses) with NC8- pSIP411, NC8-pSIP411-VP1, WCFS1-pSIP411, WCFS1-pSIP411-VP1 or milk. Animals immunized with NC8-pSIP411-VP1 and WCFS1-pSIP411-VP1 developed high levels of antigen-specific serum IgG, IgA, IgM, mucosal secretory IgA (sIgA) and neutralizing antibodies, and revealed stronger cell-mediated immune responses and enhanced protection against FMDV challenge compared with control groups. The recombinant pSIP411-VP1 effectively improved immunoprotection against FMDV in guinea pigs.

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Wang, M., Pan, L., Zhou, P., Lv, J., Zhang, Z., Wang, Y., & Zhang, Y. (2015). Protection against foot-and-mouth disease virus in Guinea pigs via oral administration of recombinant Lactobacillus plantarum expressing VP1. PLoS ONE, 10(12). https://doi.org/10.1371/journal.pone.0143750

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