Synthesis, biological evaluation and docking studies of 4-hydroxycoumarin derivatives as anti-liver cancer agents

Abstract

The synthesis and characterization of new 4-hydroxycoumarin derivatives (1-6) were realized by means of infrared spectroscopy (IR), 1H nuclearmagnetic resonance spectroscopy (1H NMR), high resolution mass spectrum (HRMS) and single crystal X-ray crystallography. The anticancer activity of these compounds was investigated against four human liver cancer cells (SMMC-7721, Bel-7402, MHCC97 and Hep3B) by 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide (MTT) assay. Furthermore, molecular docking studies supported the biological assay data and suggested that compounds 1 and 2 may be potential anticancer agents.