α-glucosidase inhibitory activity of Shorea belangeran of Kerangas forest

Abstract

Objective: Screening of anti-diabetic activity of some plants was conducted by having ethno botanical survey. Methodology: Laboratory analysis was also shown to obtain the bioactivity of S. belangeran(Shorea belangeran). Bioactivities of methanol extract from leaves and barks of S belangeranare: (i) Qualitative phytochemical compound and (ii) Anti-diabetic activity. Qualitative phytochemical compound was analyzed by colour visualization method. Anti-diabetic activity was determined based on inhibitory activity to α-glucosidase enzyme. Results: The result displays that parts of plant of S. belangeran of the Kerangas forest have various phytochemical compounds. Methanol extract from the bark of S. belangeran has a concentration index of 50% (IC50) to α-glucosidase enzyme at 0.816 ppm concentration. This appearances that the methanol extract of S. belangeran potentially have an anti diabetic activity, even though the IC50 of glucobay is in 0,167 ppm concentration. Conclusion: The bioactivity identification of some tree species is an important step to have a high economical value of Kerangas forest.