Vital capacity and selected metabolic diseases in middle-aged Japanese men

Abstract

Objective: To elucidate the association between vital capacity and the presence of selected metabolic diseases in middle-aged Japanese men. Methods: A cross-sectional analysis of the associations among forced vital capacity (FVC), Static vital capacity as a percentage of that predicted (%VC) and the presence of metabolic diseases was performed. Results: In a univariate linear regression analysis, PVC and %VC were inversely associated with poor vegetable intake, cigarette smoking and body mass index, but not with physical activity or ethanol consumption. In a logistic regression analysis adjusted for lifestyle factors, body mass index and age, the odds ratios for the presence of metabolic disease per 0.54 L (1 SD) decrease in FVC were 1.24 (95% CI 1.03 to 1.50) for type II diabetes, 1.21 (95% CI 1.02 to 1.42) for hypertension, 1.34 (95% CI 1.11 to 1.63) for hypertriglyceridemia, 1.23 (95% CI 1.03 to 1.46) for high gamma-glutamyl transferase levels and 1.63 (95% Cl 1.10 to 2.41) for an episode of cardiovascular disease. FVC did not correlate with hyperhomocysteinemia, hypercholesterolemia or high white blood cell count. Similar results were also obtained for the association between %VC and metabolic diseases. Conclusions: A decrease in FVC or % VC was associated with the presence of some metabolic diseases. The association may partly explain the reported association between low FVC and cardiovascular disease. ©2006 Pulsus Group Inc. All rights reserved.