Targeting estrogen receptor sites in human breast cancer cell line T47D with copper conjugates of nonsteriodal anti-inflammatory drug derivatives: Antiproliferative activity of ketoprofen derivative and its copper complex

Abstract

A square planar copper complex of derivatized NSAID drug (Ketoprofen thiosemicarbazone [3-benzoyl-α-methyl benzene acetic acid thiosemicarbazone]), is characterized by elemental analysis, spectroscopy, electrochemistry and magnetic susceptibility studies which exhibits dose-dependent and enhanced antiproliferative effects on human breast cancer cell line T47D rich in progesterone receptors.