Experimental and kinetic modelling study of NC palladacycles mechanosynthesis

Abstract

Ball mill mechanosynthesis provides a method for direct C-H activation to prepare NC palladacycle precatalysts via liquid-assisted grinding (LAG). Methanol and dimethylsulfoxide were used as non-innocent LAG reagents, coordinating to the Pd center and producing more reactive intermediates to speed reactions. Kinetic modelling results are consistent with a mechanism of nucleation and autocatalytic growth in these processes.