Facile synthetic routes to prepare α-muricholic acid, hyocholic acid, and their taurine conjugates

Abstract

α-Muricholic acid was synthesized through 9 steps from chenodeoxycholic acid with 26% overall yield. Hyocholic acid was synthesized through 8 steps from the same starting material with 63% overall yield. Taurine conjugates of α-muricholic acid and hyocholic acid were also prepared via their pentafluorophenyl ester.