Constituintes químicos e avaliação das atividades antioxidante e anti-inflamatória das raízes de sabicea brasiliensis wernh (rubiaceae)

Abstract

Chemical constituents and evaluation of antioxidant and anti-inflammatory activities of roots of Sabicea brasiliensis Wernh (Rubiaceae). The phytochemical investigation of Sabicea brasiliensis roots led to the isolation of 5-O-caffeoylquinic acid, 3,5-and 4,5-O-dicaffeoylquinics acids, scopoletin, ursolic acid, a mixture of β-sitosterol, stigmasterol and campesterol, daucosterol and saccharose. The structures of the isolated compounds were assigned on the basis of one-and twodimensional NMR spectroscopic methods and by comparison with literature data. The anti-inflammatory and antioxidant activities of the crude methanolic extract and its fractions were analyzed.