The anti-inflammatory activity of zerumbone (1), a natural cyclic sesquiterpene isolated from Zingiber zerumbet Smith was investigated using carrageenan-induced paw edema and cotton pellet-induced granuloma tissue formation test in mice. It was demonstrated that intraperitoneal administration of 1 at a dose of 5, 10, 50 and 100 mg/kg produced significant dose-dependent inhibition of paw edema induced by carrageenan. It was also demonstrated that 1 at similar doses significantly suppressed granulomatous tissue formation in cotton pellet-induced granuloma test. © 2010 Elsevier B.V. All rights reserved.
CITATION STYLE
Sulaiman, M. R., Perimal, E. K., Akhtar, M. N., Mohamad, A. S., Khalid, M. H., Tasrip, N. A., … Israf, D. A. (2010). Anti-inflammatory effect of zerumbone on acute and chronic inflammation models in mice. Fitoterapia, 81(7), 855–858. https://doi.org/10.1016/j.fitote.2010.05.009
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