Potent and selective inhibitors of human peptidylglycine α-amidating monooxygenase

Abstract

Fatty acid glycolates are nanomolar inhibitors of small cell lung carcinoma peptidylglycine α-amidating monooxygenase, with binding affinities orders of magnitude stronger than those of the analogous thioesters, the corresponding substrate glycine derivatives or the natural substrate procalcitonin. © 2011 The Royal Society of Chemistry.