Pharmacokinetics and distribution of a biodegradable drug-carrier

Abstract

This paper describes tissue distribution, blood clearance and excretion of biodegradable cyanoacrylic nanoparticles. After intravenous administration, nanoparticles were rapidly cleared from the blood stream and concentrated mainly in the reticuloendothelial system. When administrated subcutaneously, nanoparticles seemed to avoid the liver and the spleen whereas they concentrated in the gut wall. Whole body autoradiography performed on Lewis Lung carcinoma-bearing mice showed progressive accumulation of the carrier in tumoral tissue. Furthermore a high level of radioactivity was found in the metastatic lungs of cancerous animals, whereas no lung accumulation was observed in healthy mice. Data are given concerning the enzymatic contribution to the degradation of the nanoparticles in vivo. © 1983.