Comparative study of single dose versus multiple doses of antibiotic prophylaxis in caesarean delivery

Abstract

Background: The aim of this study was to compare the low dose of vaginal misoprostol and dinoprostone gel for the induction of labour at term of pregnancy.Methods: Retrospective comparative study was undertaken on 300 subjects with 2 parallel treatment groups. Data were analyzed using Graphpad Instat 3 McIntosh software by Student’s t test, Mann–Whitney U test, the Chi-squared test or fisher’s exact test.Results: Comparatively narrow spectrum low cost cefotaxime is as effective as more expensive commonly used amoxicillin-clavulanic acid with no significant difference of infectious morbidity.Conclusions: Less costly cefotaxime should be preferred compared to more costly triple drug regimen for prophylaxis at caesarean section.