1-Deoxysphingolipids and Their Analogs in Foods: The Occurrence and Potential Impact on Human Health

Abstract

1-Deoxysphingolipids (1-deoxySLs) are structurally distinguished from canonical sphingolipids (SLs) by absenting the essential C1-OH group that can be found in the daily diet, especially in seafoods. Excessive production of endogenous 1-deoxySLs is involved in multiple diseases. Within this review, we discuss the presence of 1-deoxySLs and their analogs from the diet and their potential physiological and pathophysiological aspects. 1-DeoxySLs as dietary and endogenously produced components are still full of mysteries and research gaps that warrant further attention.