Synthesis Characterization and Antimicrobial Activity of N-nitroso-2, 6-Diphenylpiperidin-4-One Semicarbazone

Abstract

Piperidin-4-ones mostly display varied and potent biological properties such as Antiviral, Antitumour, Analgesic, Antimicrobial, Fungicidal, Herbicidal, Insecticidal, Antihistaminic, Anti-inflammatory and Anticancer. CNS stimulant and recent reports suggest that compounds containing piperidin-4-one moiety elicit excellent activity when aromatic substitutions are present at 2-and/or 6-positions. In this work, the compound N-nitroso-2,6-diphenylpiperidin-4-one semicarbazone has been prepared and analyzed. The product showed positive nitrogen test (Lassign test), a single spot in TLC and sharp melting point for the purity of the compound. The structure of the compound was further confirmed from the CHN analysis FT-IR, and 1 H NMR Spectral data and the compound have being screened for its antimicrobial activity against gram positive bacteria Bacillus subtilis, Staphylococcus aureus and Gram-negative bacteria Escherichia coli by using Ciprofloxacin as standard and fungi Candida albicans by using Cetramazole as standard. The compound exhibited significant activities against all the tested bacterial and fungal strains.