Abstract
Interleukin-5 (IL-5) has been shown to be a selective eosinophil growth and differentiation factor. In the present study, the effect of recombinant human IL-5 on human eosinophil sulfidopeptide leukotriene production was investigated. IL-5 did not affect leukotriene synthesis in unstimulated eosinophils. However, IL-5 potentiated leukotriene synthesis by eosinophils stimulated with serum treated zymosan (STZ) or the calcium ionophore A23187 by 69% and 135%, respectively. The priming effect of IL-5 was dose dependent, with significant stimulation occurring at 1 000 U/ml for STZ and 100-1 000 U/ml for A23187. Pre-incubation with IL-5 did not increase leukotriene synthesis further. © 1994, Rapid Communications of Oxford Ltd.
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Van Oosterhout, A. J. M., Van Der Poel, A., Nijkamp, F. P., Roos, D., & Koenderman, L. (1994). Lnterleukin-5 potentiates sulfidopeptide leukotriene production by human eosinophils. Mediators of Inflammation, 3(1), 53–55. https://doi.org/10.1155/S0962935194000098
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