Evaluation Of Oxidative Stress And Its Association With Pro-Inflammatory Cytokines In Obese, And Non-Obese PCOS Subjects

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is a common endocrinological disorder of reproductive age female. The etiology of PCOS is not completely understood. Several publications nowadays demonstrate the relationship between chronic low-grade inflammation and mitochondrial dysfunctions induced by oxidative stress. Methods: This hospital based cross-sectional study, was conducted among reproductive age females. The study includes 73 obese PCOS, 55 Lean PCOS subjects and 15 non-obese PCOS subjects on the basis on transvaginal sonography and BMI. The anthropometric parameters were: BMI, Waist Hip Ratio (WHR), systolic and diastolic blood pressure by sphygmomanometer. Serum samples were collected to measure: oxidative stress (MDA), lipid profile, and pro-inflammatory cytokines (HsCRP, IL-6, IL-18 & TNF-α). Results: The BMI and MDA levels were significant in obese-PCOS and lean PCOS group (p <0.001). Whereas, in the obese-PCOS and non-PCOS obese group MDA, triglycerides, HDL, VLDL, IL-6, IL-18, and TNF-α were significant respectively. Conclusion: It concluded from this study that obesity may contribute to dyslipidemia and elevated oxidative stress levels in reproductive age females irrespective of PCOS. Therefore, obesity in addition to known features such as dyslipidemia, hypertension and disturbed oxidative stress response, may be contributing factors to increase the risk of future cardiovascular diseases in obese women.