MR imaging - Based localized intra-arterial thrombolysis assisted by mechanical clot disruption for acute ischemic stroke due to middle cerebral artery occlusion

8Citations
Citations of this article
60Readers
Mendeley users who have this article in their library.

Abstract

BACKGROUND AND PURPOSE: LIT-MCD is used in our institution for acute stroke due to MCA occlusion, with the goal of reducing symptomatic intracranial hemorrhage by maintaining recanalization of the occluded vessels. The purpose of the study was to investigate the safety and efficacy of LIT-MCD and to identify factors associated with a poor outcome in patients undergoing this procedure. MATERIALS AND METHODS: LIT-MCD for MCA occlusion was performed in 90 of 1907 consecutive patients with acute stroke admitted to our institution. Radiographic data and clinical outcome were evaluated in the 90 patients, and factors predictive of a poor outcome (3-month mRS score, 3-6) were investigated by multivariate analysis. RESULTS: Recanalization was achieved in 73 of the 90 patients (81%); symptomatic intracranial hemorrhage occurred in 7 (8%); procedure-related complications, in 9 (10%); and a favorable clinical outcome (3-month mRS score, 0-2), in 48 (53%). A high baseline NIHSS score (≥20), a low preprocedural ASPECTS on MR imaging (≤7), proximal M1 occlusion (in the horizontal segment of the MCA at or proximal to the lenticulostriate arteries), and no recanalization were significant predictors of a poor clinical outcome. CONCLUSIONS: LIT-MCD is a safe and effective treatment for acute stroke due to MCA occlusion. However, further intervention is needed to improve the outcome of patients with proximal M1 occlusion. Copyright © 2011 by the American Society of Neuroradiology.

References Powered by Scopus

Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: A randomized controlled trial

2832Citations
N/AReaders
Get full text

Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy

2142Citations
N/AReaders
Get full text

Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke.

1363Citations
N/AReaders
Get full text

Cited by Powered by Scopus

What is meant by "TICI"?

123Citations
N/AReaders
Get full text

Clarifying differences among thrombolysis in cerebral infarction scale variants: Is the artery half open or half closed?

66Citations
N/AReaders
Get full text

Multisociety consensus quality improvement guidelines for intraarterial catheter-directed treatment of acute ischemic stroke, from the American Society of Neuroradiology, Canadian Interventional Radiology Association, Cardiovascular and Interventional Radiological Society of Europe, Society for Cardiovascular Angiography and Interventions, Society of Interventional Radiology, ..

29Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Imai, K., Mori, T., Izumoto, H., Watanabe, M., Kunieda, T., Takabatake, N., & Yamamoto, S. (2011). MR imaging - Based localized intra-arterial thrombolysis assisted by mechanical clot disruption for acute ischemic stroke due to middle cerebral artery occlusion. American Journal of Neuroradiology, 32(4), 748–752. https://doi.org/10.3174/ajnr.A2353

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 17

55%

Researcher 12

39%

Professor / Associate Prof. 2

6%

Readers' Discipline

Tooltip

Medicine and Dentistry 26

81%

Agricultural and Biological Sciences 4

13%

Pharmacology, Toxicology and Pharmaceut... 1

3%

Computer Science 1

3%

Save time finding and organizing research with Mendeley

Sign up for free