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A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates

Chemistry - A European Journal (2015) 21(43) 15133-15137
DOI: 10.1002/chem.201502999
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Abstract

By replacing the central thiophene unit of an anionic pentameric oligothiophene with other heterocyclic moities, a palette of pentameric thiophene-based ligands with distinct fluorescent properties were synthesized. All ligands displayed superior selectivity towards recombinant amyloid fibrils as well as disease-associated protein aggregates in tissue sections.

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Shirani, H., Linares, M., Sigurdson, C. J., Lindgren, M., Norman, P., & Nilsson, K. P. R. (2015). A Palette of Fluorescent Thiophene-Based Ligands for the Identification of Protein Aggregates. Chemistry - A European Journal, 21(43), 15133–15137. https://doi.org/10.1002/chem.201502999

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