Synthesis, Antitumor, Antimicrobial and Anti-Hepatities B Activities of New 3-(4-chlorophenyl)-N-(p-tolyl)acrylamide Chalcone Derivatives

Abstract

New substituted pyrimidine, pyrazole, pyridine and pyrrole derivatives were synthesized from an unsaturated arylacetylmine key derivative via cyclization reaction with the suitable corresponding reagent and their structures were characterized by elemental and spectral analyses. The synthesised compounds' anticancer, antibacterial, and anti-Hepatitis B efficacy was investigated against a variety of cells and microorganisms. Most of the studied substances had moderate to high activity, according to the data.