Syntaxin13 expression is regulated by mammalian target of rapamycin (mTOR) in injured neurons to promote axon regeneration

Abstract

Background: Axon regeneration following nerve injury depends on activation of mTOR. Results: Nerve injury increases the expression of syntaxin13 in an mTOR-dependent manner. Conclusion: Injury-induced synthesis of syntaxin13 is important for axon regeneration. Significance: Learning which proteins are synthesized via mTOR in injured nerves is crucial to our understanding of regenerative mechanisms in peripheral neurons. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.