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Decoding MHC loss: Molecular mechanisms and implications for immune resistance in cancer

  • Lin P
  • Lin Y
  • Chen X
  • et al.
Clinical and Translational Medicine (2025) 15(7)
DOI: 10.1002/ctm2.70403
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Abstract

Graphical Abstract 1. Tumour cells evade immune surveillance by downregulating MHC expression through transcriptional repression, lysosomal degradation and post-translational modifications. 2. Pharmacological agents interventing epigenetic and metabolic can upregulate MHC expression and improve T cell activation. 3. Combination strategies potentiate immunotherapy efficacy by reinvigorating tumour immunogenicity. Clin. Transl. Med. 2025;15:e70403. wileyonlinelibrary.com/journal/ctm2 https://doi.

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APA

Lin, P., Lin, Y., Chen, X., Zhao, X., & Cui, L. (2025). Decoding MHC loss: Molecular mechanisms and implications for immune resistance in cancer. Clinical and Translational Medicine, 15(7). https://doi.org/10.1002/ctm2.70403

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