CTLA-4 has potent regulatory effects on the threshold of T-cell signalling and, in the process, guards against the development of hyper-proliferation and autoimmunity. Despite this, the role of CTLA-4 on specific T-cell subsets has been unclear. Such studies could shed light on both the function of CTLA-4, and on the contribution of the subsets to the disease phenotype of the Ctla4-/- mouse. Recently, a role for this co-receptor in the function of Treg has been outlined and, in this issue of the European Journal of Immunology, the selective targeting of the T-box transcription factor Eomes by CTLA-4 in the regulation of CD8+ cytolytic T-cell (CTL) effector function is shown. Together, these papers shed light on the role of CTLA-4 in different T-cell subsets. © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
CITATION STYLE
Rudd, C. E. (2009). CTLA-4 co-receptor impacts on the function of Treg and CD8+ T-cell subsets. European Journal of Immunology. https://doi.org/10.1002/eji.200939261
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