SP350RESPONSE TO VACCINATION ANTI HEPATITIS B IN ADVANCED CHRONIC KIDNEY DISEASE (CKD) PATIENTS NOT REQUIRING DIALYSIS, COMPARING TWO DIFFERENTS VACCINES

Abstract

Introduction and Aims: It is well-known the poor response to anti Hepatitis B vaccination, in patients under Dialysis program and the improvements achieved when this is made in Pre-dialysis phase. This case study's Objective is analyze the response to this vaccination, comparing two different vaccines, ENGERIX B(DNA, adsorbed) and FENDRIX B(DNA adsorbed and adyuvanted with MPL). Methods: Patients and Methods.- 115 patients were included,73 Men,42Women, average age X:67,3±11.6, with CKD grade 4-5 (MDRD-4: 15.17± 5) 2° to common etiologies. Previously HbsAg, HbcAb and HbsAb were determined, and, 2 months after the treatment, HbsAb. Vaccination pattern was the same for everyone: (0,1,2,y 6 months) and was repeated with no response. 62 patients (Group A) were administrated by EngerixB, 40 mcg IM for each one , and 53(Group B) Fendrix B, 20 mcg. Positive response was considered, when HbsAb title was ≥10 mUI/ml. Both groups were similar in terms of age, eGF, and etiology. Results: Positive response was found in 81 patients and 10 more in a 2° attempt. Total: 91(79.1{%}). This data is similar to both groups (A 80.3{%}, B:79.2{%}). Patients under 75 years old(70{%}), reponsed by 91.2{%}(A:92{%},B:88.5{%}), against patients above 75 years old, responsing by 48{%}(A:54,B:36{%}) p{