Challenge and promise: The role of miRNA for pathogenesis and progression of malignant melanoma

Abstract

MicroRNAs are endogenous noncoding RNAs that are implicated in gene regulation. More recently, miRNAs have been shown to play a pivotal role in multiple cellular processes that interfere with tumorigenesis. Here we summarize the essential role of microRNAs for human cancer with special focus on malignant melanoma and the promising perspectives for cancer therapies. © Springer-Verlag 2010.