Flow-injection analysis for meloxicam based on tris(2,2′-bipyridine) ruthenium(II)-Ce(IV) chemiluminescent system

Abstract

It was found that meloxicam could enhance the chemiluminescence (CL) of the tris(2,2′-bipyridine) ruthenium(II)Ce(IV) system in the medium of sulfate acid. Based on this phenomenon a new flow-injection system with chemiluminescent detection has been proposed for determination of meloxicam. Under optimum conditions, meloxicam had a good linear relationship with the CL intensity in the concentration range of 6.0 × 10-4 to 1.0 μg/mL and the detection limit was 3.7 × 10-4 μg/mL. The proposed method was applied to detect meloxicam in tablets and a satisfactory recovery was obtained. The possible mechanism for this CL system is also discussed in this paper. © 2009 John Wiley & Sons, Ltd.