Reduction and preparation of a phthalimide derivative from a furo-heliangolide

Abstract

Goyazensolide, a biologically active natural product classified as a furo-heliangolide, was transformed in a phthalimide derivative that showed an enhanced biological activity against Tripanosoma cruzi. The complex natural product was also reduced with high stereoselectivity by hydrogen/Wilkinson's catalyst; an epimer of this product was obtained in the reduction with hydrogen/Pd-C.